Dr. Stephen Hsu, a tenured professor of Oral Biology and Diagnostic Sciences at the Dental College of Georgia, is a world-renowned expert in green tea polyphenol research and inventor of green tea technology-derived products and medications, which treat dry mouth, dandruff, hair loss, cold sores, and viral infections with natural ingredients. Dr. Hsu was awarded a number of patents on novel technologies targeting autoimmune diseases, herpes simplex virus, virus-induced infections, and salivary dysfunction (xerostomia or dry mouth). Dr. Hsu has been selected as a TED speaker in 2014. Dr. Hsu received the International Association for Dental Research (IADR)/GSK Innovation in Oral Care Award in 2011. In 2015, he received the Georgia Bio Innovation Award for his unique inventions. Also in 2015, Dr. Hsu received the Oral Discoveries & Inventions Award from Georgia Dental Association (GDA). Dr. Hsu has been invited to appear on numerous TV and radio/podcast programs, and frequently invited to international conferences as a keynote speaker.
VIDEO - DUwHF #1158 - Stephen Hsu
AUDIO - DUwHF #1158 - Stephen Hsu
Dr. Hsu earned a bachelor’s degree in biochemistry from Wuhan University after a six-year forced labor experience in a rural farm in China. After moving to the United States, he received a Master of Arts degree in molecular biology from Montclair State University in New Jersey and a Ph.D. in cell biology and anatomy from the University of Cincinnati, College of Medicine. He completed a postdoctoral fellowship at Memorial Sloan-Kettering Cancer Center in New York City before a career change to television. During the four years as a television commentator and sports anchor for ESPN International, Dr. Hsu taught at the National University of Singapore as a Lecturer. In 1998, Dr. Hsu received the Ruth L. Kirstein Research Service Award from the National Cancer Institute, and conducted cancer research at New York University School of Medicine. Dr. Hsu joined the Augusta University, formerly the Medical College of Georgia, in 1999 and serves as Course Director for Nutrition and Course Director for Biochemistry in the Department of Oral Biology and Diagnostic Sciences. Dr. Hsu has joint appointments in the Institute of Molecular Medicine and Genetics and the Graduate School. He is a former President of the Georgia chapter of the American Association for Dental Research and a member of the American Association for Cancer Research and the International Association for Dental Research. He has published more than seventy research articles in peer-reviewed scientific journals, eight books or book chapters, and has presented his research findings at scientific meetings worldwide, as well as lectured for CE courses to dentists, dental hygienists, and pharmacists. He has served as reviewer of grant applications for the National Institutes of Health (NIH), U.S. Department of Defense (DOD), the National University of Singapore, and for numerous scientific journals. Dr. Hsu’s research has been funded by the NIH and the U.S. Department of Defense, IADR, Georgia Research Alliance (GRA), among other organizations. Dr. Hsu has collaborated with researchers representing the fields of oral biology/maxillofacial pathology, dermatology, virology, and molecular biology from Universities in the US, China, and Japan. He and his wife, Tracy, live in Evans, Georgia with their sons, Alexander and Andrew.
Howard: It's just a huge honor for you today to be podcast interviewing Dr. Stephen Hsu PhD He is the founder and chairman of Camellix, a professor of oral biology and diagnostic, he's a tenured professor of oral biology and diagnostic sciences at the Dental College of Georgia. A world-renowned expert in green tea polyphenols and inventor of green tea technology derived products and medications which treat dry mouth, dandruff, hair loss, cold sores and viral infections with natural ingredients. Dr. Hsu was awarded seven patents on novel technologies targeting autoimmune disease herpes simplex virus virus induce infections and salivary dysfunctions like xerostomia. Dr. Hsu has been selected as a TED speaker I watched that again today that's why I called him to be on the show you have to watch his TED talk he's just amazing I hope he goes over some of his TED talk today. He received the International Association for dental research with a IADR for a GSK innovation and oral care award in 2011. In 2015 he received the Georgia bio Innovation Award for his unique inventions. He received the oral discoveries and inventions from the Georgia Dental Association Dr. Hsu has been invited to appear on numerous TV and radio podcast programs frequently invited to international conferences as a keynote speaker. He earned a Bachelor degree in biochemistry from Wuhan University in the city of Wuhan China after a six-year forced-labor experience in rural farm in China after moving to the United States and received a Masters of Arts degree in molecular biology from Montclair State University in New Jersey and a PhD in cell biology and Anatomy from the University of Cincinnati College of Medicine. He completed a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center in New York City before a career change to television. During the four years as a television commentator and sports anchor for ESPN international, Dr. Hsu taught at the national University of Singapore as a lecturer. In 98 they received the Ruth L kirstine research award from the National Cancer Institute and conducted cancer research at New York University School of Medicine. Dr. Hsu joined the Augusta University formerly known as the Medical College Georgia in 99 and serves as course director for nutrition and course director for biochemistry in the Department of oral biology and diagnostic services. He has joint appointments in the Institute of molecular medicine and genetics and the grad school he is former president of the Georgia chapter of the American Association for dental research and a member of the American Association and cancer research and the International Association for dental research. He has published more than 70 research articles in peer-reviewed scientific journals, eight books or chapters has presented his research findings of scientific meetings worldwide as well as lectured for CE courses to dentists hygienists and pharmacists. He has served as a reviewer of grant applications for the NIH, the Department of Defense, the National University of Singapore and for numerous scientific journals. Dr. Hsu research has been funded by the NIH and the US Department of Defense IAD our Georgia Research Alliance among other organizations. He has collaborated with researchers representing the fields of oral biology and maxillofacial pathology, dermatology, vitalogy and molecular biology from the universities in the United States China and Japan he and his wife Tracy live in Evans, Georgia with their sons Alexander and Andrew. My gosh I'm gonna say you are the smartest person I've ever had come on my show thank you so much for coming on the show today to talk to all these dentists and hygienists commuting to work how are you doing today?
Stephen: Pretty good nice to be here thank you for the introduction.
Howard: My gosh your TED talk I mean I think people especially these young kids they don't realize the cultural revolution you live through there, I don't know if you want to start with that but that's start with the culture revolution because so many kids that they don't even know about it.
Stephen: You know cultural revolution actually you started in 1966 not quite a long time ago
Stephen: 1966 yeah at that time I was a I just became a teenager just became a teenager, so I actually witnessed the entire episode the cultural tragedy and all these kind of broken families and the people so many people died and persecuted. So my family was one of them my family due to the background because my father came back from United States to China he went back to China because my grandpa was ill and then he was trapped in China and never had a pension to get out of a country so at that time meant my father was accused as a CIA spy so my family was totally turned upside down and therefore I was not given any education opportunity so after the middle school I was forced to go to a labor camp they called re-education re-educate. So I went to the labor camp when I was 16 and all the way till I was almost 23 before the Revolution was over in 1976 therefore I could have opportunity to go to college and then so I tried hard and eventually I get into my university I'm passing the college entrance exam and so that's what I started and then eventually become what I am right now.
Howard: How many people actually died do you think in the Cultural Revolution?
Stephen: For me you know since I was like 11, 12 years old I have witnessed witnessed a lot of people commit suicide, persecuted, they couldn't take any more and so for people cultural revolutionary they were just them you know brought to somewhere and have a big meeting and get shot you know after that they buy the squad of the execution squad. So I witnessed so many of them and also there are some Fighting's between a lot of groups they did they fought with you know with cannons you believe or not with with automatic weapons. So I also witnessed that so that was like very big big chaos in the whole country you know.
Howard: Yeah the reason I want to turn that is a lot of kids are listening right now probably about a quarter of the people listening to you are still in dental school and the rest are probably under thirty, Millennials old people like you and I read books and journals and papers and they they like internet and a lot of them are playing a violin feeling sorry for themselves because they're graduating with $400,000 of the student loans I'm like well were you born and raised during the Cultural Revolution. I mean these kids a day that are that are crying in their soup don't realize some of the horrors that the last generation lived through.
Stephen: Exactly exactly, so I was really fortunate I was just one of the fortunate person that actually I could you know through hard work to get education college education but my peers you know all these middle school kids they went to the farm the majority 99% of them did not get reasonable education. So right now they're all retired that not really or not you know retirement age for China is like 60 years they're all retired I'm still working hard as well as happy. You know I'm still contributing to the mankind contributing to the dentistry and the medicine.
Howard: Well you know I want to ask you before we start, how do people like yourself remain positive through such hard times? I mean you you I would give you so much credit if you just were depressed and drunk and just you know just wallowing and you know. How did you come out of this with such a positive productive attitude?
Stephen: I think that's there are a lot of factors the I think the major factor is that from my family background for me for me is from my family background so the Xu family has a long history in the Chinese history and so our family for several generations has been doing pretty well and my grandpa and he also served for the garment and he's got his big brother my grandpa the big brother was the president of China Mr. Shichang Hsu he was a president from 1918 to 1922 and so I have a lot of good role models to make sure that I need to follow up and contribute to the people and so I was determined you know also I was in a such a harsh situation during the time that I lost hope almost. So I survived that that labor camp I survived cultural revolution and I made related to higher education therefore you know for me I would say you know I was very very focused and make sure that I'll move forward and make sure all these effort will be benefiting the human population especially for the Americans and because I came over here as a young man and I received all these support from American taxpayers making the scholarship for PhD all these taxpayers and then the grants we were funded in only needs from the federal government so I'm so appreciative for the support so I need to achieve a lot of things that is my goal and so we're working hard you know we have a good team is working hard and make sure that our product will be the best will be most effective and to help people.
Howard: Why do they call you the green tea doctor?
Stephen: The green guy, see I'm drinking green tea all the time it's not because of that is not because of green tea I'm drinking is the benefits of green tea that really helped me very very early in the years when we in the farm because in the farm there was no running water there was no toilet system you know. So we have been drinking all the dirty water that the rain collected, all kinds of whatever contaminations therefore I was a severely ill and due to the probably the germs and then the local farmers local farmers they just told me it has you know you can't drink something the boiled this kind of leaves the boil to notice this is the tea leaves over all the tea leaves. So I was actually benefited from the green tea actually from tea during my early time that helped my diarrhea and the contamination. I really felt a little so I have some really self personal experience over the benefits therefore I came over here 20 years ago I came here and they study the benefits of green tea compounds because green tea was created originally as a medicine in China and later a thousand years ago a thousand years ago it became a very popular beverage therefore a lot of people they just drinking this beverage however people they did not forget it has medicinal benefits but that benefit was a potential I need to be brought out so that I was the one that already a lot of work on the benefit of these compounds, how to make these compound making formulations for different variety of products and potentially drugs to help people. So because this is non toxic and also as natural and also has a lot of multiple multiple benefits antioxidant, anti-inflammatory and anti-cancer you name it, there's so many research you know about 10,000 publication already you know in the web you can search.
Howard: So I always think of the United the Western Hemisphere the Americas as coffee drinking and the eastern hemisphere Europe, Africa, China, tea do you see tea rising up against coffee?
Stephen: Well when you talk about the coffee yet it's very popular in the whole world actually in China in Japan you know you go anywhere with it even the tea drinking countries they adapted there are a lot of coffee because you know Starbucks. Starbucks opened everywhere in China and Japan you can find out all the airport however tea drinking actually increase year after year at the year and tea drinking especially green tea green tea has growing for multiple folks in certain countries including the United States there are a lot of import the green tea and other types of tea therefore we see a very big increase in key consumption in the United States. So that's a good thing that's a very good thing combined with many other behavior changes that we see the benefits can be received by people the population they consume tea the consume green tea that also they consume coffee. Coffee has some benefits too for cardiovascular from other benefits. So therefore no we hope with the public getting healthier and healthy.
Howard: So your talk about the journey of starting Camellix and what exactly does that name mean? Camellix.
Stephen: For scientific name of the tea plants called camellia sinensis, therefore we're talking about how can we utilize the compound to convert that into products, medications to help people therefore we use the first Camelli and then we could x at the last x aims prescription you know one day some prescription drug will come there is already one prescription drug from Grady compa they're gonna be more so therefore for green tea to be used in medicinal purpose that's the name of Camellix.
Howard: Wow that is I learned something every day, so Camellix the name of your company is from camellias sinensis which is a species of evergreen shrub or small tree whose leaves and leaf buds are used to produce tea, white tea, yellow tea, green tea, dark tea and black tea are all harvested from one or the other but are processed differently to attain varying degrees. Now now talk about your journey of starting this company or you what kind of green tea products are you or I see Mighteaflow I see all kinds of different products with water what are you what what green tea products are you selling?
Stephen: The first one that we have developed the first one we had together for the Mighteaflow product is the Mighteaflow dry mouth chewing gum, so that's a very first and still right now this this comes like this. So this come so this is still selling very very well and so welcomed by the people with xerostomia, so that's the first product developed. I was serving as a consultant before Camellix was formed but later on our school the technology transfer office encouraged me to apply for some grants from the state the Georgia Research Alliance to form a company that develop products based on our inventions, our patents. So in the beginning I was just like oh I'm a professor I'm teaching to research you know, I cannot be business you know leader but they encouraged me to try that and so we get the grant we get our formulation together and we became independent and then we start our product line. So the first product will be the that the dry mouth chewing gum, then very popular this is my popular lozenge this is the lozenge.
Howard: Explain the name is it Mighteaflow
Stephen: Right Mighteaflow, the mighty flow right it is sold in many different small pharmacies online Amazon and then we have the same very small see this is very small bottle is the spray, you can just for people very convenient it is just spray into their oral cavity and then a big bottle this is the rinse also. So we have where the lineup for dry malice because with so many people they have dry mouth they don't know which one is best for them so we search a lot we have a dental team we have a dentist, we have a statistician, a pathologist. All these experts put together to develop this formula and on top of that we put that formula into clinical trial in our dental school, the Dental College of Georgia and then after that the trial that we found actually the formula actually can restore were not talking about stimulation would happen restore the function at least partially of the salivary gland that means unstimulated saliva is elevated 400 four hundred percent four hundred percent four-fold increase in unstimulated saliva. This is something unheard of no you see a lot of products they can stimulate of course and stimulate you chew up a wax you can stimulate but for unstimulated saliva this is the most media level for people suffer from dry mouth because without stimulation now their saliva flow is very very slow. So only when they restored their salary gland function then they can improve their quality of life that's exactly we did and then that is exactly we published.
Howard: So let's back up a little bit, who suffers from dry mouth, xerostomia?
Stephen: The biggest of population biggest percentage who suffer from dry mouth are the people taking a lot of prescription medications. There are more than 400 medications there are common medications that cause dry mouth. So if you watching the commercials at the end of a commercial there's all this product could cause dry mouth there's so many of them and then there is a small population like a 1 to 3 million of those people they suffer from a disease called Sjogren's syndrome those people they have the most severe dry mouths because their salivary gland is attacked by their own immune system therefore the function is lost and then there's some a population that be publishing their cancer therapy a patient, oncology patients after therapy chemo or radiation therapy and their cancers and they will suffer not only try my other other problems of hair loss the different problem infections in oral cavity.
Howard: Well if you go to dentaltown and there's a quarter million dentists on dentaltown and we're coming up on our 20-year anniversary the st. Patrick's Day but if you do a search for a Sjogren's syndrome, you find so many threads on Sjogren's syndrome and I wish you would go I wish you would go on dentaltown do a search for dry mouth xerostomia Trojans and post some of these videos and I know what their first question is going to be, how does how does green tea extracts from your company Camellix how does it actually treat xerostomia xerostomia?
Stephen: Xerostomia is something that people they feel and that mouth is dry it's different than the salivary gland dysfunction so we call them a xerostomia. So a lot of people didn't print together I'd give a lot of lectures a lot of CE's or to tell them you know the difference is some people they do feel dry but actually they do not have the salivary dysfunction but what we talk about is that people with reduced saliva flow, that's the bigger problem causing complications. So therefore waiting out of a study so first we do some cellular study molecular study and then we eventually with step onto the animal models we did three animal studies and based on the Sjogren's model that they are salivary gland is attacked by new facility attrition and then getting damaged so therefore that they are very very close to human Sjogren's cases and pathology. Therefore we found that you know before the onset of the disease actually their gland already had some changes the DNA damage caused by free radicals were apparent and then the enzymes fighting these free radicals decreased and eventually eventually they will lose the function little by little, so that's the problem in the secretive clans like a salary and the pancreas and so all these glands are getting attacked there for the animals actually drinking the compounds had very very little effect compared to the animals that drinking only water. So we thought wow something something is happening to really keep the norm in the glands you know when the compounds from green tea were introduced into the animal models therefore we believe that the compounds actually can really help with the glandular function with a lot of for the research on certain enzymes certain signal transduction elements and we found that was the case therefore the group of us Dr. turocy Dr. perky Dr. Dickinson and Dr. Mooney and is also but big team picked him so we start to search for the actually formula and we try different combinations of natural compounds and other plain compounds we tried and then one loud um one not the formulation that really really has a very prolonged prolonged effect for celebrate flow rate therefore we made that as mighteaflow because the T is in the middle and the flow of saliva. So that come up the name and the formula.
Howard: I've been reading a lot lately that they're starting to find it now that everybody's donating their DNA and finding out their ancestry and they've got millions samples that I've read some papers that some researchers are finding out that these autoimmune disease tend to cluster in families especially like if someone in your like like type one diabetes, arthritis iliacs through multiple sclerosis hypothyroidism Sjogren's syndrome. They're finding those in family tree so there there has to be a genetic component then wouldn't there?
Stephen: There must be yes I agree with you absolutely and also you see the population difference too and for example the type one those type one diabetes and also Sjogren's are high in Western countries but not very and high in China see there's a big difference and that could be genetic it could be environment that could be the combination with genetic and environmental factors and I think in Japan that you can see a similar trend too. There for the know if you compare the green tea consuming population versus the not green tea consumer population that you can see a lot of difference and when these people come over here so these people like the Asian people the Japanese you have Chinese people that come here in the US and they are in the environment and now you see those disease a lot of different diseases there is like breast cancer just for example. So this is something that scientists still try to unveil the the cause and the mechanism yeah.
Howard: When you say it's higher in there's more autoimmune like celiac sprue and all that in Western versus Eastern some people link that because Westerners eat more wheat where Asians eat more rice and that there's a very big difference between wheat and rice as far as number of genes chromosomes etc. Do you think diet plays into that factor too?
Stephen: Absolutely a diet is a big a big human behavior factor that between the Western and between the populations are some different diet structures but you look into Japan when you look at it Japan they have quite different diet system than us and they stay that way they don't change see they really keep that way. So you can see the the average you know life expectancy the different diseases they are quite stable but in China after the Kentucky Fried Chicken opened in 1989 in Beijing we saw huge change of everything now China has took over of the biggest obesity population in the world China is number one now.
Howard: Oh my gosh are you kidding me?
Stephen: and China took over the type 2 diabetes the absolute number and the percentage of the world as number one. You see how fast you know 40 years 40 years past and you seen all these kind of behavior changes led to the population's health status so that is something really really online and in the u.s. you know I'm the course director for nutrition I'm trying to you know watch people how to eat how to exercise how to move on and then now we see there's a trend the cancer rate going down you see that from the nineteen nineties a cancer rate going down in the u.s. right now because of cessation of smoking. The very simple change very simple change of behavior will be due to disease statistics change very significantly. So we we still have a long way to go to to study the environmental impact of our particular public.
Howard: Well I think your company is on the right track because I'm you know the one of the major differences I've seen thirty years after graduating dental school as is patient somewhat to try something natural they're tired and lately they've lost trust in Big Pharma. I mean look I mean you're you're an expert in viruses I mean did you ever think we'd be having measles outbreaks because Millennials don't believe in vaccination.
Stephen: This is shocking right this is a shocking the measles now is topping out you know the outbreak in so many states in the US and some other part of in the world. So that's something that because people they ignored for a long time Oh measles you know we already have vaccinated you know the public has no problem well they come back you know the virus the I study viruses a lot virus dates are not stupid you know they are smart they know they know how to hide for example herpes you cannot develop a herpes to vaccine we spend so much money so many so so much time they hide from your immune system but that they come out hey they'll hurt you and also like a measles you know they pop-up and for example there's some other popular norovirus, norovirus you know every year in the United States 21 million people get infected and every year there was no reduction we have you know all kinds of prevention...
Howard: Which virus?
Stephen: Norovirus, cruise ship virus, norovirus. So our grant from NIH so it is funded us one point four million dollars you know to study and to develop a approach using spray hand sanitizer and wipes that contains green tea compounds against Norovirus to get rid of them. So that's the current project we're doing now, so you can see that these viruses you know they are not going away you know they can have all kinds of resistant strains coming out you have a drug they will develop resistance you have another drug they will develop resistance. So sometimes people say oh yeah we can have vaccines with about new vaccines well or you can see the flu the flu vaccine well how many vaccines I have and then the flu virus they keep changing and then which is sometimes we will miss them you know have to pretend for next year so in predictions wrong then the flu would become a pandemic like last year in nineteen 2017-2018 is pandemic.
Howard: I always think it's funny when people are they always you know humans are always biased about themselves everything revolves around humans and they always talk about what's the chance that humans will kill extinct each other in World War three it's like dude I think you have a much higher chance of getting extinct from a virus or a comet hitting the earth than being then having all the humans kill each other. What do you think is more diverse... I mean they say they say half of all the hundred billion humans that ever lived died of malaria.
Stephen: Yeah there are people dying from malaria too and especially in those countries Africa but when we talk about the virus I talked about viruses a hundred years ago a hundred years ago in Spain a starving in Spain that killed like up to 50 million people this is wiped them out it's a flu virus is nothing special is there flu bars but it's more more pathologic a cause more severe a problem. So we have something really really the alarm it is already a sound by the World Health Organization and they listed the top 10 micro organisms that actually wipe humans out all of them a viruses if you check on that.
Howard: and what was that list called? What was that list called, that the top 10 what is it, the top 10 viruses?
Stephen: The top 10 germs that you know the need a priority then you top priority to develop approaches to prevent and the treat the World Health I will send you that information.
Howard: No I wish you'd post it on dentaltown.
Howard: Yeah well said there's a quarter million dentists on dentaltown and we're coming up on our 20 year anniversary and I never would have thought 20 years ago we started that dentists are posting questions all the time. I mean pediatric dentists are having problems where they want to post signs that they don't want to treat your child if they're not vaccinated but then other parents say well if my child's vaccinated why do I care if the child next to me is unvaccinated. What would you give give a pediatric dentist verbage to if the people well first of all do you recommend that a pediatric dentist not see children that are unvaccinated and then if an unvaccinated mother child his mother says well look if doctor Hsu is vaccine for measles and why does he care if my kid isn't vaccinated or even has measles because if you have a vaccination for measles why do you care that my kid is sitting next to you and he hasn't been vaccinated. That's a question that dentists are now starting to hear all the time, how would you answer that?
Stephen: I think the best place to see to seek guidelines at CDC website, the CDC website has the best information to recommend for different age group you know for example not only children but also senior population and the regular public. So they do have very specific guidelines for health care settings or healthcare workers and for the entire population and also ethics plays a important role too that you know whether you deny or whatever you you must or whatever all kinds of choices that ethics and also CDC guidelines that's very very important. However I would say for me for me I would say prevention is the key prevention prevention prevention you know you want okay to get rid of those germs before it enters in your body that's the most important most effective way because when we talk about our prevent vaccination. The vaccination is arguable but when we talk about prevention or not vaccination relies on infection to work so that's something a lot of people they don't know they don't care you know vaccination without the infection vaccination would not work right you're gravely powerless because vaccination cannot prevent virus to infect you but only prevent the symptom either reduce or make it you know a word so that's something that we focus on we focus on prevention we want to develop approaches to kill these virus before the impact they can impact you. So that's something that we're working on supported by the NIH grant.
Howard: So if so the dentists and hygienists listening to you today if they have patients that have dry mouth would they order Mighteaflow from your website www.camellix.com C AME L Li X so it's basically camel licks camellix.com. Would you recommend that the dental office orders the Mighteaflow and dispenses it to the patient or just give them the name of the website and that the consumer orders it off of your website or is it available on amazon.com?
Stephen: Yeah Amazon Prime but they can order it from amazon prime for the patients however when you get into the Camellix.com that you get a professional and then from that button that you can reach the company for free samples they can send to your clinic and for your patient to try and for you to try it for free. You see that's something that I think people can take advantage of because we really want people to know that this type of natural product that went through a clinical trial and shows a restoration of the salivary gland function and help people with their saliva flow and help to manage their dry mouth.
Howard: Okay so if you go to just think of that camel lix he's got a button there, professionals to request free samples.
Stephen: Also see this is the new sanitizer hand sanitizer that is placed in every single dental unit in our dental school hundreds of them so our entire dental school only uses this Center the protec team sanitizer why are twofold of benefits, first we know alcohol that really can hurt your skin dry or skin and making irritant and this one does not have that in fact second regular regular alcohol sanitizer they only can claim to kill bacteria, bacteria and some viruses however with the compound active green and active EGCG this sanitizer can kill a lot of nasty viruses. So that's the advantage the two photo advantages and we have so now we're developing try to develop a whole line of this type of products.
Howard: So you it says on your website that protect I protect Protecteav right, Preotecteav. I love your names your your your marketing is very good you work you work Tea into all these deals. So tea all these things so you set it on the active EGCG lethal viruses what would is EGCG?
Stephen: EGCG is one of the compounds that present in large amount in the tea leaves but in order for them to be active against the virus that needs a technology to make certain make certain process. So this is the protective technology that we possess and we have already patent that technology therefore is not only in the in the sanitizer but also you can see from the the Cold sore treatment of Averteax. So that's the cold sore treatment right here.
Howard: Yes okay so we've talked about we talked about Protecteav, we talked about Mighteaflow but that one was Averteax?
Stephen: Averteax, yes
Howard: Okay talk about it.
Stephen: Averteax came out came out is also utilize this technology to activity EGCG that technology and also went through a phase two clinical trial for cold sore patients because I used to get a lot of cold sore because I stress because I love traveling and so I always try to use one very popular cold sore very small tube and then it did not work very well do you not work by well so since our research showed it has so high efficacy against the virus so we tried we try to formulate and then we try the clinical trial and we found that result was really really shocking. The result actually shortened the episode from a median of nine days to four point five days and we publish that result triple all everybody knows that's the oral medicine magazine and also we look at the blister and oscillation time duration and we can actually shorten that from three days to one day. Therefore when you use that medication actually you can stop blister within one day average average. So that's something that we were very very excited about it therefore from which we want to develop a prescription drugs for all kinds of problem like the genital herpes and also we wanted to look at it you know whether the flu can be can be addressed because the flu pandemic is so terrible so we want to see whether we can develope some control methods for prevention of the flu.
Howard: We started the show talking about chairman mao's and the cultural revolution I don't think most people around the world realize that the Spanish influenza during the time of World war one actually killed more people than all of World War One.
Stephen: Exactly up to 50 million people get killed.
Howard: Anyway let's go back to the Cold War because it's a very we're social animals and people feel so conscious when they have a cold sore I mean some people literally don't even want to go to school or going to work. So now in the thirty years I practice what do you think was the most common treatment for a cold sore? What do what do you think most dentists are treating with today?
Stephen: I think the first we have to recognize the dental professionals to them cold sore or or herpes lady anis herpes stomatitis this type of open sore pose a hazard to dental professionals we need to be very careful every time I go for a CE we'll just tell them you know can be very very careful not only touching but also aerosol could in opacity so you have a wound there are many many report on that so that's the first one, the second one the concern must be addressed because cold sore is a herpes virus that popping out when you are under stress your immune system get a little reduce the cold sore will come out you know different places especially on your lips and also inside the oral cavity. So it is a self-healing disease that will probably will complete each episode within 10 and 14 days but that's a long time the long time and looks very bad. So right now the approach is to how to deal with that episode to reduce them, so there are many many antiviral drugs that people can prescribe and people they can put it on there either either topical or systemic use these drugs from what I can see their efficacy is very weak it is very weak for some simple tropical applications is not very strong systemically infusion it can be very strong however what they cause they cause side effects they can have some kind of a kidney problem too but the biggest factor risk is to induce the virus to mutate to mutate that become a bigger problem the way we are producing superbugs super virus that's something that we need to be very careful just like antibiotics, too much antibiotics you're inducing superbug. Now we have Mrsa we have a little multiple resistant to bug that we're coming around you cannot even control therefore virus same thing we already isolated so many different strains that resistant to antibiotics. Not for people but also flu virus they have on resistant strains to. We have to be very very careful. The advantage of our technology is that our product using the compound the active is EGCG this compound works on multiple mechanisms it's not only for one pathway or one molecule or one enzyme the virus can mutate anytime but we have this compound that work multiple mechanisms these are all published data which is the everybody can check. This way these viruses they have no way to develop resistant they just die so that's why the cost for medication the Averteax works so well and you can see the reviews you can see Amazon or you can look at our publication triple all you can see that worked it so well this virus you don't have to worry about you know side effect you don't have to worry about environmental pollution you have to worry about that embarrassed to mutate so that's something that managed the people should take.
Howard: There's a thread on dentaltown in fact it was a and two very popular thread this one that's one of the articles about one hygienist saying that when she has a patient that comes in with a cold sore she wants to rescheduled them and of course the dentist is thinking well I have overhead I can't pay you $40 an hour to reschedule a patient with a cold sore. Where do you weigh in on that?
Stephen: Well according to of the guidelines doctor all I can say according to the guidelines depends on the size of the of the lesion and depends on the weather that can be contained. So the daintiest make decision believe I am that dentist I am the dentist if I look at the cold sore is the outbreak it has I don't see the viral shadings very very current I probably would suggest that they she'll come back after the sore is not in care of because I cause a threat a risk to everybody in the clinic. There are many publication on that, there are many publications on that you can you can see that.
Howard: So you talk about Mighteaflow, Revitealize, Averteax, you still have another product you have four products the that was the hair loss hair care I wasn't going to cover that today since I don't have any care any hair so I don't think it means anything to me but just in case someone's listening that has hair talk about your hair product.
Stephen: Yeah the hair product was also among the earliest product we launched and basically it take advantage of the antioxidant properties of the green tea compounds plus another plant compound that can help with the hair follicles but therefore that we develop that compound for two purposes and see one of them one of them for the right right here this is the blue bottle and so this one is for hair loss. Especially right now a lot of a cancer patients after they went through therapies and their hair loss they can actually use that to wash their hair but the other type is the blue bottle that's the for dandruff the dandruff also we know that a lot of caused by the immune system problems and the overgrow of the epidermis and the shedding of these skin cells. So that's inflammation therefore we use natural anti information to combat this type of problems so we have this product line to address in the way natural way the point actress and also we pick all the ingredients according to the standard of the Environmental Working Group website so the website they have all these kind of compounds they analyze all these ingredients for the shampoo. So we choose non-toxic green compounds so therefore we develop that hair care products to control of dandruff and also to help people with thinning hair. So I use them I use them every day I actually I use all these products from time to time but I use the shampoo every day. I use these sanitizer every day so that's something now.
Howard: and you get that you got the dental school to put the hand sanitizer.
Stephen: Entire yeah the entire dental school hundreds more then four hundred dental chairs four hundred dental units and many many offices find resolve is that they all use our sanitizer because sometimes there's a one there's one staff that I tell you the story the one staff on her desk it has our sanitizer which is provided by the school and another sanitizer I said okay why you're using another Sennheiser she said hey your sanitizer is so gentle I don't believe he's gonna kill the bugs I used the tough one that really you know we dry my skin all that must be working for the bacteria I said well and this is the purpose the we want a good sanitizer and get rid of the bugs then she believed because publications. Well all these publications out and that you can check on that.
Howard: Well I still have patients that only want to switch their mouths with Listerine because it burns and feels like you know...
Stephen: Exactly yes that actually can cause cancer you know from some studies high alcohol content.
Howard: and do you think it's the high alcohol content on the oral tissue or the fact that if you're an alcoholic you destroyed so much of your liver do you think do you think they're mixing out drinking alcohol with rinsing alcohol on tissues or needs that you think do you think Listerine on oral tissue by itself is carcinogenic?
Stephen: Yes from study see when we talk about a study we'll talk about evidence-based dentistry so evidence-based dentistry we could see a lot of evidence because see a lot of evidence that alcohol is a factor is that one factor one of the factors associated with oral cancer, okay tobacco is another one when you combine them it's getting worse so the alcohol content was very high like the old mystery obviously and has very high content of alcohol they have a low alcohol now they have an alcohol now. I think it's much better so any alcohol content too high you know more than 10 percent that may not be a good option may not be a good option so that's from scientific evidence we see that that could lead to increased risk of oral cancer.
Howard: A lot of the dentists that are as old as me when they see someone with a cold sore they're still thinking acyclovir what would you say to someone he thinks he's listening to you saying for your you know to stop blisters talk about Averteax verses acyclovir.
Stephen: Yes acyclovir is the oldest antiviral that been used for decades against the certain of our infections and either can be taken as systemically or can be used as oilmen or gel topical applications and their clinical study showed the clinical study of acyclovir show the topical application of a sickle where can reduce the episode by you know how long, less than that day reduce the entire episode a less than a day the people one day for them can be can be you know making a big difference but the Averteax in our clinical trial data showed can reduce this episode by four point five days I think that's a big difference.
Howard: I think you could change a lot of minds just going to I mean you basically you basically right right now you have four products mighteaflow, Revitealize, Averteax, Proacteav you should get on dentaltown and do a search for these cold sores or blisters but and tell them what you know because it's not like you're some salesman from a company. I mean you're you're from you're a PhD from a dental school you should really come on and educate them because...
Stephen: Everything is evidence based.
Howard: Yeah so you have four products now what's gonna be your fifth product some day?
Stephen: Not someday I think we are projected it to launch the next product that's gonna be the very sidle spray against norovirus and germs so that can be very exciting so this is the product that we are developing supported by the National Institute of Health that we're in the we're in the stage try to finalize that and the needs to get a pool by EPA EPA and then when you look at this spray, when you look at our spray in your dental office in on the surface you know to clean them and then you see there are sprays that claims to kill germs and viruses norovirus whatever's and you need to be very careful you need to be careful look at their contents so that's all I can say you know I don't want to say too much you can see there they are ingredients you can see their pH you can see their compounds in there so that's something that we are developing something so natural that will not hurt anything will not have a corrosive in fact material but also has very very high efficacy against norovirus and other viruses and and the bacteria. So doesn't very exciting where we're developing that and also we're talking about another product is the wipe so the white and you can do that the same purposes.
Howard: You know when you're talking about your hand sanitizer lotion everything I'm reading is telling me that my smartphone is probably filthier than my hands is that is your hand sanitizer something when you put it on your hand sanitizer do you think people should pick up their smartphones and rub it on the Smartphone or...
Stephen: When the spray come out that could be very very good whether the smartphone's I think is clean actually it's cleaner that day your keyboard probably
Howard: Seriously okay
Stephen: The keyboard accumulated a lot of stuff that because you do not clean up see I do not clean them you know every day but your smartphone sometime you clean them you wipe them out and use some certain wipes so the wipes you can really clean up pretty well but your keyboard you know make sure door knobs and there's a lot of places that people touch if they have a lot of germs why go to the gym see I go to gym very frequently and I see people there using different running products you know I have to say in a more education are needed because the gym all these equipment that you do right and what they do you know they do not clean their hands they clean those equipment is useless, you clean the equipment you first you make sure your hands are clean that's the most important before you touch anything.
Howard: Yeah so long ago is there anything we didn't talk about today that you that I wasn't smart enough to ask you about is there any any other areas you want to talk about?
Stephen: I think you are covered a lot and I think for the dental office the dental settings okay he's a confined place usually and also the lot of crowds and the people traffic over the place that we need to be really really careful about infectious disease we need to keep in mind it doesn't matter to me those that matter is flu or herpes but there's something we cannot see for example HPV we cannot see them from people their oral cavity when you open up when you take a oral exam and you don't see any lesion however my put in a white while you're doing your procedure this patient may have a viral shedding they do not have any symptom. So you need be very careful about the PPE may be very careful what about your hand piece and the son especially the suction piece make sure aerosol okay does not go to you or go to your assistant or some other patients and then make sure the cross-contamination of your dental chair of your dental in surface and your waiting room all these places that we need to be very careful because when you have a norovirus outbreak in your office then you will have some big tasks, you have to report a CDC do all kinds of things under the guidelines at the clean up and you know you have to stop. So a lot of things that we need to be very careful and then we need to you know the dental professionals we're in the frontline. We see symptom first we know people we meet them every six months not like their physicians so we need to be very very careful.
Howard: Well I'm you just mentioned I was gonna let you finish with that but now you just open up another question I got asked you know over time. You know dentist don't like being called a dentist they they want to be a physician of the oral mouth a doctor of the mouth but usually but you don't see them really behind vaccinations for HPV like Gardasil I mean there's thousands of dentists listening to you right now who have never even talked to their patient about Gardasil. If you're really gonna be a physician of the oral cavity doesn't the HPV vaccination have to be part of your routine conversation?
Stephen: Well at least we need to review the chart we need to review the patient's history and to see whether at their teenager time you know they were vaccinated or not and if you're not you know that could be you know something because the HPV population is getting bigger and bigger and some other viral infractions getting bigger and bigger for example the herpes know herpes one and herpes two. Herpes one and but HPV is the most dangerous one that's associated with oral cancer and some other sites. So oral cancer is now it's definitely associated with HPV especially the 16th 18th other strengths so that need to be really look at it and then if you pay attention to the patient history and then you'll be more better prepared.
Howard: Well I tell you what this has been an amazing show I can't wait I hope you get on dentaltown and bring up everybody's education on this it's Dr. Stephen Hsu, PhD professor of oral biology, founder of Camellix, Mighteaflow, Revitealize, Averteax and Proacteav. Thank you so much for coming on the show today and if you ever have more information you're always welcome to come back on the show because you know so much about this stuff. Thank you so much for all that you've done my final question do you ever get back to China?
Stephen: Yes of course we do have some business that link to China because of the technology of green tea originated from China so we try to take advantage of that and so we do have some pieces linked over there.
Howard: Yeah I think one of the most fun lectures I ever gave was in Shenzhen my gosh modern modern dental labs in Shenzhen I think they have 4,000 employees and I got to tour all over China oh my gosh what an amazing country and it is just beyond amazing but thank you so much for coming on the show today.
Stephen: My pleasure
Howard: It was an honor to podcasts interview you.